List of top Questions asked in Graduate Pharmacy Aptitude Test- 2022

In the case of halogenation reaction of alkanes, abstract of primary hydrogen yields a primary radical, and abstract of secondary hydrogen yields a secondary radical.
\(\mathrm{R-H} + \mathrm{Br}^- \longrightarrow \mathrm{R}^- + \mathrm{Br-H}\)
The above example is of:

Identify the correct descending order of strength of nucleophilic solvents from the below‐given options:

Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to

Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class 
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme 
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme 
Choose the correct answer from the options given below:

Ethylketazocine is a 6,7‐benzomorphan derivative with _____ receptor selectivity.

Which of the following is NOT a cause for the drug undergoing nonlinear pharmacokinetics

When 100 mL of 0.1 M sodium hydroxide solution is added to 100 mL of 0.1 M acetic acid (Ka = 1.82 x 10^-5 ), pH of the solution will be _____ .

Nitric oxide synthase exists in ____.

Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and

List I		List II
A	Constant heat (q = 0)	I	Isothermal
B	Reversible process at constant temperature (dT = 0)	II	Isometric
C	Constant volume (dV = 0)	III	Adiabatic
D	Constant pressure (dP = 0)	IV	Isobar

Choose the correct answer from the options given below:

Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:

The titration of a strong acid with a strong base is represented by plot _____ .

Potential at the equivalence point for a redox reaction
\(\mathrm{aOX1} + \mathrm{bRED2} \rightleftharpoons \mathrm{bOX2} + \mathrm{aRED1}\)
is given by the equation:

According to Mohr method, the silver nitrate solution can be standardized against primary‐ standard grade:

Regarding Bromocriptine, which of the following statement is TRUE‐ It is a relatively selective dopamine D2 agonist with prominent action
A. on pituitary lactotrophs (inhibit prolactin release) 
B. in striatum (antiparkinsonian) 
C. in CTZ (antiemetic) ATP γ K 5) 6) 7) 
D. as an adjunctive treatment for type 2 DM 
Choose the correct answer from the options given below:

The major product formed in the above‐given Knorr synthesis is:

Match List I with List II

	List I-Buffers		List II-pH Value
A	HCl and KCl	I	8 to 10
B	HCl and Potassium Hydrogen Phthalate	II	2.2 to 4.0
C	NaOH and Potassium Hydrogen Phthalate	III	1.2 to 2.2
D	H3BO3, NaOH, and KCl	IV	4.2 to 5.8

Choose the correct answer from the options given below:

Back‐titration method is used for
A. Volatile substances 
B. Insoluble substances 
C. Substances for which a quantitative reaction proceeds rapidly only in the presence of excess of the reagent 
D. Substances that require heating with a volumetric reagent during the determination, in which decomposition or loss of the reactants would occur in the process 
Choose the correct answer from the options given below:

HPTLC analysis is useful for following types of analysis of herbal drugs
A. Quantitative estimation of marker compound 
B. Authentication of extracts 
C. Detection of pesticides 
D. Standardization of herbal drugs 
Choose the correct answer from the options given below:

Stability index, determined for evaluating the stability of oil–water viscous emulsions, based on electric conductivity changes during non‐destructive short heating–cooling–heating cycles,
A. is defined as \(\frac{Δ}{h}\), where h is the change in the conductivity between 35°C and 45°C and Δ is the conductivity interval within the two heating curves at 35°C 
B. indicates the relative change in enthalpy between two cycles 
C. is defined as \(\frac{2Δ}{h}\), where h is the change in the conductivity between 35°C and 45°C and Δ is the conductivity interval within the two heating curves at 35°C 
D. indicates the relative change in conductivity between two cycles 
Choose the correct answer from the options given below:

Anthranilic acid is an immediate precursor in the formation of

In the process of sugar coating, to prevent moisture penetration into the tablet core, which one of the following step is performed?

___ is the practice of pharmacy in private and government‐owned hospitals, health maintenance organizations (HMOs), clinics, walk‐in health centers, and nursing homes.

Given below are two statements
Statement I: Drugs Controller General of India is the Chairman of Drugs Technical Advisory Board (DTAB) 
Statement II: In DTAB, there will be eight ex‐officio members, five nominated and five elected members 
In light of the above statements, choose the most appropriate answer from the options given below