List of top Pharmaceutical Chemistry Questions asked in Graduate Pharmacy Aptitude Test

Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class 
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme 
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme 
Choose the correct answer from the options given below:

Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and

List I		List II
A	Constant heat (q = 0)	I	Isothermal
B	Reversible process at constant temperature (dT = 0)	II	Isometric
C	Constant volume (dV = 0)	III	Adiabatic
D	Constant pressure (dP = 0)	IV	Isobar

Choose the correct answer from the options given below:

Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:

Match the symbols in the List I with the terms used in the List II of conductance measurements, and

List I Symbols		List II Terms
A	\(\Omega^{-1}\)	I	Specific conductance
B	\(∧\)	II	Electrical conductance
C	k	III	Specific resistance
D	\(\rho\)	IV	Equivalent conductance

Choose the correct answer from the options given below:

Cottrell’s method is used for the measurement of:

Silver nitrate reagent is used for limit test in Indian Pharmacopoeia for

Vigabatrin produces anti-epileptic activity through

A diuretic compound cyclothiazide has a ____ substituent at C-3 of 1,2,4- benzothioadiazine nucleus?

Prostaglandin analogous have therapeutic utility in the following EXCEPT

Which of the following drug belongs to class of antibiotic called ansamycins?

Substitution constant for meta benzoic acids is denoted by

Formation of pyranose structure from glucose leads to formation of diastereoisomers called

Identify the diuretic which causes hyperuricaemia, tend to raise serum calcium and also causes magnesium depletion?

The mechanism of antiepileptic effect of Lamotrigine is by:

Hydrated proton is called _____.

Meloxicam belongs to which class of Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?

The antiemetic activity of glycopyrronium is related to potent inhibition of___receptor both peripherally and centrally.

This semi synthetic derivative of penicillin is synthesized by acylation of 6-APA with p-hydroxy phenyl glycine :

Conversion Of a carbonyl functionality directly to its hydrocarbon in basic media can be achieved by

Which of the following directly inhibits Factor Xa?

What software programme is used to determine the Verloop steric parameter in QSAR?

Select the a-lactamase inhibitor.

Catechu is used in medicine as an:-

Which of the following is a suitable antidote for mercury poisoning?