List of top Pharmaceutical Chemistry Questions on Different classes of therapeutic drugs asked in Graduate Pharmacy Aptitude Test

Tetracycline undergoes epimerization at C4 between pH 4-8 to give:

The fluoroquinolones act by:

Match the following disease with their test for detection:

Disease		Diagnostic tests
P.	Tuberculosis	(i)	Lepromin test
Q.	AIDS	(ii)	ELISA
R.	Syphilis	(iii)	Mantoux test
S.	Leprosy	(iv)	Kahn's test

Which ring of warfarin is essential for its therapeutic activity:

Which of the following drug does NOT require therapeutic drug monitoring:

5-Fluorouracil, an anti-metabolite used in cancer treatment, is activated to:

Which of the following is a third generation cephalos-Porin?

Which among the following is not used as NSAID?

Which of the following drug used in the chemotherapy of some types of leukemia, satisfies the statements:
Statement I: It is effective orally.
Statement II: It has near 100% oral bioavailability. 
In light of the above statements, choose the correct answer from the options given below:

Which of the following is NOT an example of an mTOR inhibitor?

What do you mean by Orphan Drug?

Select the correct set of anticancer drugs that belong to “pyrimidine and related compounds”:

Which of the following is a 4th Generation Cephalosporin?

Which metabolite is used to inactivate the vasico-toxic metabolite leading to hemorrhagic cystitis by alkylating agent used in the treatment of cancer

Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to

Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class 
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme 
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme 
Choose the correct answer from the options given below:

A diuretic compound cyclothiazide has a ____ substituent at C-3 of 1,2,4- benzothioadiazine nucleus?

Prostaglandin analogous have therapeutic utility in the following EXCEPT

Vigabatrin produces anti-epileptic activity through

Which of the following drug belongs to class of antibiotic called ansamycins?

The mechanism of antiepileptic effect of Lamotrigine is by:

Identify the diuretic which causes hyperuricaemia, tend to raise serum calcium and also causes magnesium depletion?

Meloxicam belongs to which class of Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?

This semi synthetic derivative of penicillin is synthesized by acylation of 6-APA with p-hydroxy phenyl glycine :

Conversion Of a carbonyl functionality directly to its hydrocarbon in basic media can be achieved by