List of top Pharmaceutical Chemistry Questions asked in Graduate Pharmacy Aptitude Test

Which of the following drug does NOT require therapeutic drug monitoring:

Match the following disease with their test for detection:

Disease		Diagnostic tests
P.	Tuberculosis	(i)	Lepromin test
Q.	AIDS	(ii)	ELISA
R.	Syphilis	(iii)	Mantoux test
S.	Leprosy	(iv)	Kahn's test

The fluoroquinolones act by:

5-Fluorouracil, an anti-metabolite used in cancer treatment, is activated to:

In a homologous series of any general anesthetic, increasing the chain length increases the lipid solubility, and produce a corresponding increase in anesthetic potency, is proposed by:

Examples of BCS class III drugs are:

Which ring of warfarin is essential for its therapeutic activity:

Tetracycline undergoes epimerization at C4 between pH 4-8 to give:

Which of the following is a third generation cephalos-Porin?

Which among the following is not used as NSAID?

Match List I with List II:

List I Name of the drug		List II Chemical class
A.	Zolpidem	I.	Cyclopyrrolone
B.	Zaleplon	II.	Benzodiazepine
C.	Zopiclone	III.	Imidazopyridine
D.	Triazolam	IV.	Pyrazolopyrimidine

Choose the correct answer from the options given below

Which of the following compound would be expected to have greatest florescence?

Which of the following drug used in the chemotherapy of some types of leukemia, satisfies the statements:
Statement I: It is effective orally.
Statement II: It has near 100% oral bioavailability. 
In light of the above statements, choose the correct answer from the options given below:

Which of the following is NOT an example of an mTOR inhibitor?

What do you mean by Orphan Drug?

Select the correct set of anticancer drugs that belong to “pyrimidine and related compounds”:

Which of the following is a 4th Generation Cephalosporin?

Which metabolite is used to inactivate the vasico-toxic metabolite leading to hemorrhagic cystitis by alkylating agent used in the treatment of cancer

Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:

Identify the functional groups from the below mentioned options that lead to weakening of benzoic acid:
(A):–OH
(B):–Cl
(C):–NH₂
(D):–NO₂

Citric acid cycle is the final pathway during the oxidation of _______ .

Heme is ____ .

All enzymes accelerate the reaction rates by______________ .

A patient with pheochromocytoma is undergoing surgery and has not been administered with alpha receptor blocker. If he is administered with intravenous propranolol, then which of the following effects will be evident?

Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to