Question

Assertion (A): Enantiomers are inseparable on simple column chromatography. Reason (R): Enantiomers bind achiral stationary phase with equal affinity and Enantiomers can be separated by using chiral stationary phase.

• A. Both (A) and (R) are correct and (R) is the correct explanation of (A)
• B. Both (A) and (R) are correct but (R) is NOT the correct explanation of (A)
• C. (A) is correct but (R) is not correct
• D. (A) is not correct but (R) is correct

Hint:

To separate "left" and "right" hands (enantiomers), you need a "glove" (chiral phase) that fits them differently.

Answer 1

The Correct Option is A

Step 1: Concept Enantiomers have identical physical properties (like boiling point, solubility, and polarity) in an achiral environment.

Step 2: Meaning Separation in chromatography depends on the difference in affinity between the solute and the stationary phase.

Step 3: Analysis Since an achiral stationary phase interacts with both enantiomers identically, they elute at the same time. To separate them, a chiral environment (chiral stationary phase) is required to form temporary diastereomeric complexes with different stabilities.

Step 4: Conclusion Both statements are correct, and the Reason successfully explains why simple (achiral) column chromatography cannot resolve enantiomers. Final Answer: (1)