Question:

Which one or more of the following statements is/are correct regarding the transport and retention of proteins in different cell organelles?

Updated On: Sep 3, 2024
  • Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.
  • Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments.
  • The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus.
  • Nuclear proteins are transported in an unfolded conformation and the nuclear localization signal sequence is subsequently cleaved by peptidases in the nucleoplasm
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The Correct Option is A, B, C

Solution and Explanation

The correct options are: (A):Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.(B):Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments. (C):The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus..
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