Question

Which one or more of the following statements is/are correct regarding the transport and retention of proteins in different cell organelles?

• A. Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.
• B. Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments.
• C. The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus.
• D. Nuclear proteins are transported in an unfolded conformation and the nuclear localization signal sequence is subsequently cleaved by peptidases in the nucleoplasm

Answer 1

The Correct Option is A, B, C

The correct options are: (A):Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.(B):Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments. (C):The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus..