Question

Which of the following statements about Primosome, which is required for primer synthesis during DNA replication in E. coli is NOT correct?

• A. Includes Dna B helicase
• B. Includes RNA synthesizing primase called DnaG
• C. Required to synthesize primers only in the leading strand
• D. Propelled in the \(5^{\prime}\rightarrow3^{\prime}\) direction along the DNA template

Hint:

Primosome: synthesizes primers for both strands.
Contains helicase and primase.
Moves \(5^{\prime}\rightarrow3^{\prime}\).

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Primosome is a complex involved in DNA replication.
It is required for primer synthesis.

Step 2: Key Formula or Approach:
No specific formula.
Need to understand the primosome complex.

Step 3: Detailed Explanation:
Primosome:
- Includes Dna B helicase (A is correct).
- Includes DnaG primase (B is correct).
- Moves in \(5^{\prime}\rightarrow3^{\prime}\) direction (D is correct).
Primosome synthesizes primers for both leading and lagging strands.
It is not only for the leading strand (C is incorrect).
Thus, the incorrect statement is that it is required only for the leading strand.

Step 4: Final Answer:
The statement "Required to synthesize primers only in the leading strand" is NOT correct.
Hence, the correct option is (C).