Question:
Which of the following is NOT an eicosanoids?
Which of the following is NOT an eicosanoids?
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Eicosanoids (20-Carbon Arachidonate derivatives): Prostaglandins, Leukotrienes, Lipoxins, Thromboxanes. Cholesterol is a 27-Carbon Sterol.
Updated On: Sep 4, 2026
- Prostanoids
- Leukotrienes
- Lipoxin
- Cholesterol
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Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Eicosanoids are 20-carbon polyunsaturated fatty acid signaling autacoids derived from membrane arachidonic acid.
Key Formula or Approach:
\[ \text{Arachidonic Acid (20:4, } \Delta^{5,8,11,14}) \xrightarrow{\text{COX / LOX Pathways}} \text{Prostanoids, Leukotrienes, Lipoxins, Thromboxanes} \]
Step 2: Detailed Explanation:
Evaluating the lipid molecules:
1. Eicosanoids: Biologically active 20-carbon lipid signaling molecules derived from arachidonic acid via cyclooxygenase (COX), lipoxygenase (LOX), or cytochrome P450 pathways. Subfamilies include Prostanoids (Prostaglandins, Prostacyclins), Leukotrienes, Lipoxins, and Thromboxanes.
2. Cholesterol: A 27-carbon tetracyclic sterol lipid synthesized from acetyl-CoA via the mevalonate pathway, not an eicosanoid.
Step 3: Final Answer:
Thus, Cholesterol is NOT an eicosanoid, matching option (D).
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