Question:
Which of the following is/are in-process QC test(s) for tablets:
Which of the following is/are in-process QC test(s) for tablets:
Updated On: Jul 14, 2026
- Zeta-sizing Test
- Hardness, Friability, Average weight
- Drug content, Puncture Test
- Dissolution Test
Show Solution
Verified By Collegedunia
The Correct Option is B
Approach Solution - 1
The correct option is (B): Hardness, Friability, Average weight.
Was this answer helpful?
0
0
Show Solution
Verified By Collegedunia
Approach Solution -2
In-process quality control tests are the checks performed while a tablet batch is actually being compressed, not after the finished batch is packed. The question asks which listed set of tests belongs to that in-process stage.
- Zeta-sizing Test: Zeta potential and particle sizing are used to characterize suspensions, emulsions or nanoparticle systems, not compressed tablets, so this test has no role in tablet in-process control.
- Hardness, Friability, Average weight: These three are checked repeatedly on samples pulled straight from the tablet press during compression, at set time intervals, to confirm the machine is producing tablets of consistent weight, that are hard enough to survive handling, and that will not crumble during coating or packaging. This routine, in-line sampling is the definition of in-process QC.
- Drug content, Puncture Test: Drug content uniformity is normally confirmed as a finished-product release test, and puncture testing is mainly applied to characterize the strength of coated films or packaging materials rather than being run as a routine in-process check during compression.
- Dissolution Test: Dissolution testing takes measurable time to run and is performed on the finished, fully compressed and (if applicable) coated tablet as part of final product release testing, not while the batch is still being compressed on the machine.
Because hardness, friability and average weight are the tests pulled and checked directly from the running tablet press at regular intervals, this is the set that belongs to in-process QC.
The correct answer is Hardness, Friability, Average weight.
Was this answer helpful?
0
0
Top GPAT Pharmaceutics Questions
- Which of the following is an example of a thermosetting plastic material?
- Which of the following vehicles (not required to be sterile, but must be pyrogen free) is intended to be used in the manufacture of injectable products to be sterilized after preparation?
A typical skin cream consisting of stearic acid, potassium hydroxide, glycerin, water, preservative and perfume, would be commonly known as:
- Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: The pressure filling method for filling pharmaceutical aerosol is usually preferred over cold filling method
Reason R: Because with pressure filling method high production speed can be achieved and less propellant is lost.
In light of the above statements, choose the correct answer from the options given below - Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: In the manufacturing of glycero‐gelatin suppositories, overfilling of mould is necessary.
Reason R: Glycero‐gelatin bases contract very little on cooling and the excess cannot be neatly removed.
In light of the above statements, choose the correct answer from the options given below
View More Questions
Top GPAT Tablets Questions
- In the process of sugar coating, to prevent moisture penetration into the tablet core, which one of the following step is performed?
- Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: During the process of decompression in tablet manufacturing, expansion occurs in some tablet.
Reason R: Expansion occurs in some tablet because of Plastic deformation that has occurred during compression process.
In light of the above statements, choose the correct answer from the options given below - Which one of the following manufacturing facility may not be required for oral solid dosage form?
- In the process of adding lubricant to a granulation, the lubricant is divided finely by passing it through 60‐100 mesh nylon cloth on to the granulation, in production this process is called as ____the lubricant
- Select the equation that gives the rate of drug dissolution from a tablet
View More Questions
Top GPAT Questions
- Match the symbols in the List I with the terms used in the List II of conductance measurements, and
List I
SymbolsList II
TermsA \(\Omega^{-1}\) I Specific conductance B \(∧\) II Electrical conductance C k III Specific resistance D \(\rho\) IV Equivalent conductance
Choose the correct answer from the options given below: - Cottrell’s method is used for the measurement of:
- Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and
List I
List II
A Constant heat (q = 0) I Isothermal B Reversible process at constant temperature (dT = 0) II Isometric C Constant volume (dV = 0) III Adiabatic D Constant pressure (dP = 0) IV Isobar
Choose the correct answer from the options given below: - Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:
- Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:
View More Questions