Question:
Which of the following is/are in-process QC test(s) for tablets:
Which of the following is/are in-process QC test(s) for tablets:
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In-process QC tests help ensure the consistency and quality of the manufacturing process, focusing on parameters like hardness, friability, and average weight before final product testing.
Updated On: Jul 14, 2026
- Zeta-sizing Test
- Hardness, Friability, Average weight
- Drug content, Puncture Test
- Dissolution Test
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The Correct Option is B
Approach Solution - 1
In-process quality control (QC) tests for tablets typically include hardness, friability, and average weight tests. These tests ensure that the tablets meet the required mechanical strength and weight specifications. Drug content, puncture test, and dissolution test are also important, but they may be considered final product tests rather than in-process QC tests.
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Approach Solution -2
The question asks which test(s) are carried out as in-process quality control (IPQC) for tablets, that is, checks done while the batch is still being compressed rather than after the finished tablets are packed. Let's look at each option on its own merits.
- Zeta-sizing Test: This measures the surface charge and particle size distribution of colloidal or nanoparticulate systems such as nanosuspensions and liposomes. Tablets are solid compressed dosage forms, so zeta-sizing has no place in a tablet compression line.
- Hardness, Friability, Average weight: These three checks are performed at set intervals right on the compression machine while tablets are being punched. Hardness confirms the compression force is adequate, friability confirms the tablets can survive handling, and average weight confirms uniform fill and die-cavity performance. Because these are checked continuously during manufacture, they are classic IPQC tests.
- Drug content, Puncture Test: Drug content (assay) uniformity is normally confirmed on the finished, packed batch as part of release testing, not while tablets are still being compressed. Puncture test is used for films, patches, or soft gelatin shells, not for compressed tablets.
- Dissolution Test: Dissolution is a pharmacopoeial finished-product test run on the completed batch to confirm drug release behaviour; it needs a fully formed, coated (if applicable) tablet and is not practical to run as an in-line check during compression.
Only hardness, friability, and average weight are checked repeatedly on the running compression machine, which is exactly what defines an in-process control.
Therefore, the correct answer is Hardness, Friability, Average weight.
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