Question

The correct combinations among the following:

Scientist	Event / Contribution
I. Miescher	Named nuclein
II. Fisher	Discovered purines
III. Altman	Isolated nucleic acids
IV. Franklin	DNA X-ray diffraction

• A. I & II
• B. II & IV
• C. III & IV
• D. I & IV

Hint:

Remember: Miescher discovered "nuclein" (DNA), and Franklin's X-ray images revealed DNA structure.

Answer 1

The Correct Option is D

- I. Miescher: Correct. He was the first to identify and name a substance called nuclein, now known as DNA, from pus cells in 1869.
- II. Fisher: Incorrect. While Fisher contributed to biochemistry, he is not credited with isolating nucleic acids.
- III. Altman: Incorrect. Richard Altman is known for renaming nuclein as nucleic acid, not for discovering purines.
- IV. Franklin: Correct. Rosalind Franklin produced X-ray diffraction images of DNA, which played a crucial role in discovering the DNA double helix structure.
Therefore, the correct pairs are:
- Miescher — Named nuclein
- Franklin — DNA X-ray diffraction

Answer 2

The correct combinations among the following:

I. Miescher - Named nuclein: Friedrich Miescher was the first to isolate a substance from the nuclei of white blood cells, which he called "nuclein." This substance is now known as nucleic acid.

II. Fisher - Discovered purines: This statement is incorrect. Emil Fischer did significant work on purines and sugars, but he did not discover purines.

III. Altman - Isolated nucleic acids: This is incorrect. Altman is associated with the discovery of ribozymes (RNA enzymes), not the isolation of nucleic acids.

IV. Franklin - DNA X-ray diffraction: Rosalind Franklin used X-ray crystallography to produce images of DNA, providing critical evidence of its double helix structure.

Correct Answer: I & IV