Question

Relative reactivity of the following compounds towards displacement reaction is:

• A. A $>$ B $>$ D $>$ C $>$ E
• B. A $>$ C $>$ B $>$ E $>$ D
• C. E $>$ D $>$ C $>$ B $>$ A
• D. A $>$ B $>$ C $>$ E $>$ D

Hint:

Reactivity Order: Acyl Halide $>$ Anhydride $>$ Ester $>$ Amide. Just remember the leaving group stability!

Answer 1

The Correct Option is D

Step 1: Concept Nucleophilic acyl substitution reactivity depends on the leaving group ability and the electrophilicity of the carbonyl carbon.

Step 2: Meaning A better leaving group (weaker base) makes the derivative more reactive.

Step 3: Analysis Chloride ($Cl^{-}$) is the best leaving group, making acid chlorides (A) most reactive. Carboxylate is next (B), followed by alkoxide (C). Amide ($NH_{2}^{-}$) is the poorest leaving group, making amides (D) the least reactive.

Step 4: Conclusion The reactivity order is: Acid Chloride $>$ Acid Anhydride $>$ Ester $>$ Acid $>$ Amide, which is A $>$ B $>$ C $>$ E $>$ D. Final Answer: (D)