List of top Biopharmaceutics and Pharmacokinetics Questions asked in Graduate Pharmacy Aptitude Test

Which of the following is an example of physical incompatibility:

Histogram can be drawn only for:

Which type of in-vitro-in-vivo correlation compares % drug released vs % drug absorbed?

Which of the following is true for bone tissue cell differentiation and maturation?

A hypertensive patient receiving a drug ‘Y’for managing BP was prescribed a tricyclic antidepressant. As a result, there was an abolition of the antihypertensive action of‘Y’. Which of the following drug could be ‘Y’?

A 70 kg woman was administered 1000 mg of the drug as i.v. bolus. After its uniform distribution in the body, the plasma concentration of the drug was found to be 50 mg/L. What is its volume of distribution?

Which of the following levels of IVIVC is represented by “the relatinship between one dissolution time point(e.g., t 50%) and one mean pharmacokinetic parameter, such as AUC, T_max or C_max”?

Under which of the following conditions in-vitro-in-vivo correlation for a drug fails?

In pharmacokinetic models, the term “compartment” means:

Match List I with List II

	List I		List II
A	When two dosage forms have equal t max	I	When their total body clearance is constant.
B	AUC values of the two analogs can be compared to measure relative bioavailability	II	Absorption rate constants are equal
C	Urinary data is valid to measure bioavailability. III. W	III	When fraction absorbed and elimination rate is constant.
D	C max is proportional to the rate of absorption	IV	Excretion of drug and/or metabolite is related to the bioavailable dose.

Choose the correct answer from the options given below:

For depot injections, in which drug is slowly released over weeks or months, which bioequivalence study design is used?

For solid oral drug products, a change in the concentration of which of the following excipients is more likely to influence the bioavailability of a drug.

Name the popular system for ocular delivery of pilocarpine, based on membrance -controlled reservoir systems

Chitosan possesses which of the following property?

Method of Study Drug Distribution pattern is:

For drug substances with highly variable pharmacokinetic characteristics the following Bioequivalence study design is used

A material which is insoluble and inert and used in matrix tablet formulation is:-

IVIVC utilizes the principles of statistical moment analysis:-

When Ke is constant and Ka is larger:-

In relation to buccal and sublingual route of administration which of the following statement is incorrect

Type IV dissolution apparatus as per USP is

The useful variable from in vitro dissolution test data for IVIVC includes

Diazepam is not suitable for peroral sustained release form since