Question:
Which one of the following vitamins is required for the conversion of deoxyuridine diphosphate (dUDP) to deoxythymidine diphosphate (dTDP)?
Which one of the following vitamins is required for the conversion of deoxyuridine diphosphate (dUDP) to deoxythymidine diphosphate (dTDP)?
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Folic acid (Vitamin B9):
- Required for thymidylate synthesis.
- Deficiency leads to megaloblastic anemia.
- Thymidylate synthase uses tetrahydrofolate (THF).
- Required for thymidylate synthesis.
- Deficiency leads to megaloblastic anemia.
- Thymidylate synthase uses tetrahydrofolate (THF).
Updated On: Sep 1, 2026
- Riboflavin
- Biotin
- Folic acid
- Thiamin
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Understanding the Question:
This question tests knowledge of nucleotide biosynthesis and vitamin cofactors.
Step 2: Detailed Explanation:
The conversion of dUDP to dTDP requires thymidylate synthase.
Folic acid (Vitamin B9) is required for this reaction.
Tetrahydrofolate (THF) is a methyl donor for thymidylate synthesis.
Riboflavin (A): Required for flavin coenzymes.
Biotin (B): Required for carboxylation reactions.
Thiamin (D): Required for decarboxylation reactions.
Thus, folic acid is required for dUDP to dTDP conversion.
Step 3: Final Answer:
Thus, folic acid is required, which corresponds to option (C).
[0.5cm]
This question tests knowledge of nucleotide biosynthesis and vitamin cofactors.
Step 2: Detailed Explanation:
The conversion of dUDP to dTDP requires thymidylate synthase.
Folic acid (Vitamin B9) is required for this reaction.
Tetrahydrofolate (THF) is a methyl donor for thymidylate synthesis.
Riboflavin (A): Required for flavin coenzymes.
Biotin (B): Required for carboxylation reactions.
Thiamin (D): Required for decarboxylation reactions.
Thus, folic acid is required for dUDP to dTDP conversion.
Step 3: Final Answer:
Thus, folic acid is required, which corresponds to option (C).
[0.5cm]
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