Question

Which of the following statements is NOT correct for RNA polymerase?

• A. RNA polymerase lacks separate proofreading \(3^{\prime}\rightarrow5^{\prime}\) exonuclease activity
• B. RNA synthesis occurs without Watson-Crick base pairing
• C. RNA polymerase is much bigger in size than DNA polymerase
• D. Nucleotide addition rate of RNA polymerase is 10 times more than DNA polymerase

Hint:

RNA polymerase:
No proofreading, larger size, higher rate.
Synthesis follows Watson-Crick base pairing.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
RNA polymerase is responsible for transcription.
It has specific properties different from DNA polymerase.

Step 2: Key Formula or Approach:
No specific formula.
Need to understand the properties of RNA polymerase.

Step 3: Detailed Explanation:
RNA polymerase lacks proofreading activity (A is correct).
RNA polymerase is larger than DNA polymerase (C is correct).
Nucleotide addition rate is higher for RNA polymerase (D is correct).
RNA synthesis occurs with Watson-Crick base pairing (B is incorrect).
Thus, RNA synthesis occurs without Watson-Crick base pairing is incorrect.

Step 4: Final Answer:
The incorrect statement is that RNA synthesis occurs without Watson-Crick base pairing.
Hence, the correct option is (B).