Question:
Which of the following post-translational modification of the proteins may tag them for degradation in 26S proteasome?
Which of the following post-translational modification of the proteins may tag them for degradation in 26S proteasome?
Show Hint
Polyubiquitination:
- Tags proteins for proteasomal degradation.
- Ubiquitin is a small protein (76 amino acids).
- 26S proteasome is the degradation machinery.
- Tags proteins for proteasomal degradation.
- Ubiquitin is a small protein (76 amino acids).
- 26S proteasome is the degradation machinery.
Updated On: Sep 1, 2026
- Polyubiquitination
- Biotinylation
- Prenylation
- Myristoylation
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
Step 1: Understanding the Question:
This question tests knowledge of post-translational modifications (PTMs) and protein degradation.
Step 2: Detailed Explanation:
Polyubiquitination tags proteins for degradation in the 26S proteasome.
The attachment of multiple ubiquitin molecules to a protein marks it for degradation.
The 26S proteasome recognizes and degrades polyubiquitinated proteins.
Biotinylation (B): Addition of biotin (for enzyme activity).
Prenylation (C): Addition of lipid groups (membrane association).
Myristoylation (D): Addition of myristic acid (membrane targeting).
Thus, polyubiquitination is the correct answer.
Step 3: Final Answer:
Thus, polyubiquitination tags proteins for degradation in the 26S proteasome, which corresponds to option (A).
[0.5cm]
This question tests knowledge of post-translational modifications (PTMs) and protein degradation.
Step 2: Detailed Explanation:
Polyubiquitination tags proteins for degradation in the 26S proteasome.
The attachment of multiple ubiquitin molecules to a protein marks it for degradation.
The 26S proteasome recognizes and degrades polyubiquitinated proteins.
Biotinylation (B): Addition of biotin (for enzyme activity).
Prenylation (C): Addition of lipid groups (membrane association).
Myristoylation (D): Addition of myristic acid (membrane targeting).
Thus, polyubiquitination is the correct answer.
Step 3: Final Answer:
Thus, polyubiquitination tags proteins for degradation in the 26S proteasome, which corresponds to option (A).
[0.5cm]
Was this answer helpful?
0
0
Top ICAR AIEEA Plant Biotechnology Questions
- Which of the following molecules can be classified under glycosphingolipid category?
- The bicarbonate buffer is a principal buffering system in blood plasma. The ratio of the bicarbonate to carbonic acid required to maintain pH of plasma at 7.4 is:
- Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A): The disruption of $\beta$-oxidation of fatty acids in plants can potentially reduce stress-induced ROS accumulation and improve its stress tolerance.
Reason (R): In plants, $\beta$-oxidation of fatty acids takes place predominantly in peroxisomes, where first enzyme of $\beta$-oxidation viz. fatty acyl CoA oxidase produces large amounts of hydrogen peroxide.
In light of the above statements, choose the correct answer from the options given below. - The serum level of which of the following metabolites can effectively distinguish "Vitamin B12 deficiency" from "Folate deficiency" ?
- Match List-I with List-II
List-I (Name of the Enzyme) & List-II (Class of the enzyme)
(A). Pyruvate carboxylase & (I). Oxidoreductase
(B). Fumarase & (II). Hydrolase
(C). Phospholipase & (III). Lyase
(D). Nitrogenase & (IV). Ligase
Choose the correct answer from the options given below:
View More Questions
Top ICAR AIEEA Biochemistry Questions
- Which of the following molecules can be classified under glycosphingolipid category?
- The bicarbonate buffer is a principal buffering system in blood plasma. The ratio of the bicarbonate to carbonic acid required to maintain pH of plasma at 7.4 is:
- Match List-I with List-II
List-I (Name of the Enzyme) & List-II (Class of the enzyme)
(A). Pyruvate carboxylase & (I). Oxidoreductase
(B). Fumarase & (II). Hydrolase
(C). Phospholipase & (III). Lyase
(D). Nitrogenase & (IV). Ligase
Choose the correct answer from the options given below: - Match List-I with List-II
List-I (Method) & List-II (Use in Protein Chemistry)
(A). Hydrazinolysis & (I). Site-specific cleavage of a polypeptide or protein
(B). Acid/Alkaline Hydrolysis & (II). Amino acid composition analysis of a polypeptide
& or protein
(C). Tryptic Digestion & (III). N-terminal determination of a polypeptide or protein
(D). Sanger Degradation & (IV). C-terminal determination of a polypeptide or protein
Choose the correct answer from the options given below: - The chemical linkage(s) between the $\beta$-D-glucopyranose residues in the structure of $\beta$-glucans isolated from different sources such as cereals, mushroom, bacteria and yeast could be:
(A). Both $\beta$-(1,3) and $\beta$-(1,6)
(B). Both $\beta$-(1,3) and $\beta$-(1,4)
(C). $\beta$-(1,3) only
(D). Both $\beta$-(1,4) and $\beta$-(1,6)
Choose the correct answer from the options given below:
View More Questions
Top ICAR AIEEA Questions
- Which of the following statements is false?
- Which of the following is an example of an inventory?
- According to Adam Smith, productivity gains could be brought about through .
- The supply curve for an artificially scarce good is .
- Which of the following would not be considered an opportunity cost of paid employment?
View More Questions