Question:
Which of the following is NOT a dimeric glycoprotein hormone?
Which of the following is NOT a dimeric glycoprotein hormone?
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Dimeric Glycoprotein Hormones ($lpha+eta$ chains): LH, FSH, TSH, hCG. Single-chain Protein Hormones: Prolactin (LTH), GH, ACTH.
Updated On: Sep 4, 2026
- Follicle stimulating hormone
- Luteinizing hormone
- Human chorionic gonadotropin
- Luteotropic hormone
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The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Anterior pituitary and placental gonadotropins share a common heterodimeric $lpha/eta$ glycoprotein structure, whereas prolactin/growth hormone are single-chain polypeptides.
Step 2: Detailed Explanation:
Endocrine hormone structural classification:
1. Heterodimeric Glycoprotein Hormones: Consist of two non-covalently linked glycosylated subunits (a common $\alpha$-subunit and a hormone-specific $\beta$-subunit). Examples include FSH, LH, TSH, and hCG.
2. Luteotropic Hormone (Prolactin PRL): A single-chain simple polypeptide hormone of 198 amino acids with three intramolecular disulfide bonds, belonging to the somatotropin/growth hormone family, not a dimeric glycoprotein.
Step 3: Final Answer:
Hence, Luteotropic hormone (Prolactin) is NOT a dimeric glycoprotein hormone, matching option (D).
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