Question:
The peptides containing which of the following amino acid are well suited for buffering the physiological pH?
The peptides containing which of the following amino acid are well suited for buffering the physiological pH?
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Histidine:
- pKa ≈ 6.0 (near physiological pH).
- Important in enzyme active sites and pH buffering.
- Hemoglobin uses histidine for the Bohr effect.
- pKa ≈ 6.0 (near physiological pH).
- Important in enzyme active sites and pH buffering.
- Hemoglobin uses histidine for the Bohr effect.
Updated On: Sep 1, 2026
- Histidine
- Tryptophan
- Glycine
- Cysteine
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Question:
This question tests knowledge of amino acid side chain pKa values and buffering capacity.
Step 2: Detailed Explanation:
Histidine has an imidazole side chain with a pKa of about 6.0.
This is close to the physiological pH (7.4).
Thus, histidine-containing peptides are well suited for buffering at physiological pH.
Tryptophan (B): Side chain pKa is not relevant for buffering.
Glycine (C): pKa of carboxyl group is 2.34, amino group is 9.6.
Cysteine (D): pKa of sulfhydryl group is 8.18.
Thus, histidine is the best for buffering at physiological pH.
Step 3: Final Answer:
Thus, peptides containing histidine are well suited for buffering physiological pH, which corresponds to option (A).
[0.5cm]
This question tests knowledge of amino acid side chain pKa values and buffering capacity.
Step 2: Detailed Explanation:
Histidine has an imidazole side chain with a pKa of about 6.0.
This is close to the physiological pH (7.4).
Thus, histidine-containing peptides are well suited for buffering at physiological pH.
Tryptophan (B): Side chain pKa is not relevant for buffering.
Glycine (C): pKa of carboxyl group is 2.34, amino group is 9.6.
Cysteine (D): pKa of sulfhydryl group is 8.18.
Thus, histidine is the best for buffering at physiological pH.
Step 3: Final Answer:
Thus, peptides containing histidine are well suited for buffering physiological pH, which corresponds to option (A).
[0.5cm]
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