Question:

The most active metabolite of Vitamin-D, which helps in the regulation of calcium and phosphorus metabolism is:

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1,25-(OH)2D3 (Calcitriol):
- Active form of vitamin D.
- Regulates calcium homeostasis.
- 25-OH-D3 is the major circulating form.
  • 1-hydroxy Cholecalciferol
  • 25-hydroxy Cholecalciferol
  • 1,25-dihydroxy Cholecalciferol
  • Ergocalciferol
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The Correct Option is C

Solution and Explanation

Step 1: Understanding the Question:
This question tests knowledge of Vitamin D metabolism.

Step 2: Detailed Explanation:

1,25-dihydroxy Cholecalciferol (calcitriol) is the most active metabolite of Vitamin D.
It regulates calcium and phosphorus metabolism.
25-hydroxy Cholecalciferol (B): The major circulating form (not the most active).
1-hydroxy Cholecalciferol (A): Not the most active.
Ergocalciferol (D): Vitamin D2 (plant source, less active).
Thus, 1,25-dihydroxy Cholecalciferol is the correct answer.

Step 3: Final Answer:

Thus, 1,25-dihydroxy Cholecalciferol is the most active metabolite, which corresponds to option (C).
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