Step 1: Understanding the Concept:
E. coli has several DNA polymerases.
Each has a specific function in DNA replication.
Step 2: Key Formula or Approach:
No specific formula.
Need to know the roles of DNA polymerases.
Step 3: Detailed Explanation:
DNA polymerase III is the main replicative enzyme.
It is responsible for most of the DNA synthesis.
DNA polymerase I is involved in repair and primer removal.
DNA polymerase II is involved in repair.
RNA polymerase is for transcription.
Thus, DNA polymerase III is responsible for most DNA synthesis.
Step 4: Final Answer:
DNA polymerase III is responsible for most DNA synthesis in E. coli.
Hence, the correct option is (C).