Question:
Match the LIST-I (Drug Combination) with LIST-II (Interaction):
[H]
{|l|l|l|l|}
\multicolumn{2}{|c|}{LIST-I & \multicolumn{2}{c|}{LIST-II
\multicolumn{2}{|c|}{(Drug Combination) & \multicolumn{2}{c|}{(Interaction)
A. & Penicillamine: Aluminum containing antacids & I. & Decreased plasma level
B. & Lithium carbonate: Atropine & II. & Delayed gastric emptying
C. & Oral contraceptives: Ampicillin & III. & Formulation of poorly soluble complex
D. & Amitriptyline: Phenobarbitone & IV. & Decreased reabsorption of drug
Match the LIST-I (Drug Combination) with LIST-II (Interaction):
[H]
{|l|l|l|l|}
\multicolumn{2}{|c|}{LIST-I & \multicolumn{2}{c|}{LIST-II
\multicolumn{2}{|c|}{(Drug Combination) & \multicolumn{2}{c|}{(Interaction)
A. & Penicillamine: Aluminum containing antacids & I. & Decreased plasma level
B. & Lithium carbonate: Atropine & II. & Delayed gastric emptying
C. & Oral contraceptives: Ampicillin & III. & Formulation of poorly soluble complex
D. & Amitriptyline: Phenobarbitone & IV. & Decreased reabsorption of drug
\multicolumn{2}{|c|}{(Drug Combination) & \multicolumn{2}{c|}{(Interaction)
A. & Penicillamine: Aluminum containing antacids & I. & Decreased plasma level
B. & Lithium carbonate: Atropine & II. & Delayed gastric emptying
C. & Oral contraceptives: Ampicillin & III. & Formulation of poorly soluble complex
D. & Amitriptyline: Phenobarbitone & IV. & Decreased reabsorption of drug
Show Hint
Antacids + Penicillamine = Complex (Chelation). Atropine = Anticholinergic = Delayed emptying.
Updated On: May 28, 2026
- А-II, В-III, C-IV, D-I
- A-III, B-II, C-IV, D-I
- A-III, B-I, C-IV, D-II
- A-III, B-IV, C-II, D-I
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Concept
Drug-drug interactions can occur during the absorption phase in the GI tract.
Step 2: Meaning
A. Penicillamine and Al-antacids form insoluble complexes (III). B. Atropine slows gastric emptying, delaying Lithium carbonate (II). C. Ampicillin reduces flora, decreasing oral contraceptive reabsorption (IV). D. Phenobarbitone induces metabolism, decreasing Amitriptyline levels (I).
Step 3: Analysis
Matching: A-III, B-II, C-IV, D-I.
Step 4: Conclusion
The correct sequence is A-III, B-II, C-IV, D-I.
Final Answer: (B)
Drug-drug interactions can occur during the absorption phase in the GI tract.
Step 2: Meaning
A. Penicillamine and Al-antacids form insoluble complexes (III). B. Atropine slows gastric emptying, delaying Lithium carbonate (II). C. Ampicillin reduces flora, decreasing oral contraceptive reabsorption (IV). D. Phenobarbitone induces metabolism, decreasing Amitriptyline levels (I).
Step 3: Analysis
Matching: A-III, B-II, C-IV, D-I.
Step 4: Conclusion
The correct sequence is A-III, B-II, C-IV, D-I.
Final Answer: (B)
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