Question:
In tuberculin testing, which of the following types of reaction is shown by the animal?
A. Active allergic reaction
B. Cytotoxic hypersensitivity
C. Delayed hypersensitivity
D. Arthus reaction
E. Auto-immune reaction
Choose the correct answer from the options given below:
In tuberculin testing, which of the following types of reaction is shown by the animal?
A. Active allergic reaction
B. Cytotoxic hypersensitivity
C. Delayed hypersensitivity
D. Arthus reaction
E. Auto-immune reaction
Choose the correct answer from the options given below:
A. Active allergic reaction
B. Cytotoxic hypersensitivity
C. Delayed hypersensitivity
D. Arthus reaction
E. Auto-immune reaction
Choose the correct answer from the options given below:
Show Hint
Hypersensitivity Types:
Type I = Immediate/Allergy (IgE).
Type II = Cytotoxic (Ab + Complement).
Type III = Immune Complex (Arthus reaction).
Type IV = DELAYED Hypersensitivity (T-cell mediated $\rightarrow$ Tuberculin test).
Type I = Immediate/Allergy (IgE).
Type II = Cytotoxic (Ab + Complement).
Type III = Immune Complex (Arthus reaction).
Type IV = DELAYED Hypersensitivity (T-cell mediated $\rightarrow$ Tuberculin test).
Updated On: Sep 7, 2026
- A only
- B and D only
- E only
- C only
Show Solution
Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Coombs and Gell hypersensitivity classification: the single intradermal comparative tuberculin test (SICTT) is the classical prototype of cell-mediated Type IV delayed-type hypersensitivity.
Step 2: Detailed Explanation:
Immunological mechanism of the Tuberculin Test (Mantoux Intradermal Test):
- Intradermal injection of Purified Protein Derivative (PPD tuberculin) in sensitized animals recruits sensitized memory $\text{CD4}^+$ Th1 effector lymphocytes over 48 to 72 hours.
- Th1 cells secrete pro-inflammatory cytokines (IFN-$\gamma$, TNF-$\alpha$, IL-2) that activate local macrophages, inducing vascular induration, mononuclear cell infiltration, and measurable skin-fold thickening at 48--72 hours post-injection.
- This reaction is exclusively a Type IV Delayed-Type Hypersensitivity (DTH) reaction (C only).
Step 3: Final Answer:
Therefore, the reaction shown in tuberculin testing is C only, matching option (D).
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