Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A) : Depsipeptides have more flexible structure and lower rotational barrier for cis-trans isomerization than their native analogs.
Reason (R) : One or more amide linkages in depsipeptides are replaced with corresponding ester groups leading to their reduced hydrogen bonding capacity, which in turn results in deformed secondary structures.
In light of the above statements, choose the correct answer from the options given below.