Concept:
- Treat each quadrant as its own number sequence.
- In every quadrant, the dot count in the next grid is the sum of the counts in the previous two grids.
Step 1: Record the first and third grids.
In the order top-left, top-right, bottom-left, bottom-right, the first grid has counts $(2,1,0,1)$.
The third grid has counts $(5,4,1,2)$.
Step 2: Recover the missing grid by subtraction.
For each matching quadrant, missing count equals third-grid count minus first-grid count.
$(5-2,4-1,1-0,2-1)=(3,3,1,1)$
Step 3: Check the continuation.
Adding the missing grid to the third grid gives the fourth counts quadrant by quadrant, following the same sum rule.
Thus the missing grid must contain $3,3,1,1$ dots in its four quadrants.
Step 4: Match the count pattern with the options.
Only option C has three dots in each upper quadrant and one dot in each lower quadrant.
Final Answer: Option C.