Question

Which one of the following statements is NOT correct?

• A. The graafian follicle after ovulation changes to corpus luteum.
• B. Atretic follicles are formed after atrophy of corpus luteum.
• C. Estradiol is formed from androgens in the ovarian follicle.
• D. Follicular stimulating hormone (FSH) is necessary for the development of the granulosa layer.

Hint:

Atresia happens to follicles that never reach ovulation at all, separate from what the corpus luteum is doing.

Answer 1

The Correct Option is B

Step 1: Understanding the Question.
This is a NOT correct type question about the basic physiology of the ovarian follicle, corpus luteum, and the two hormones FSH and estradiol. We need to find the one statement among four that does not hold up.

Step 2: Key Concept or Approach.
Recall the sequence of ovarian events in one cycle. A group of follicles start to grow, one dominant follicle reaches the graafian stage and ruptures at ovulation, and the ruptured follicle then turns into the corpus luteum. Follicles that do not reach ovulation degenerate on their own through a separate process called atresia, which can happen at any stage of follicle growth. Estrogen is made in the follicle from androgen building blocks, with FSH driving growth of the granulosa cell layer around the oocyte.

Step 3: Detailed Explanation.
"The graafian follicle after ovulation changes to corpus luteum" describes the normal, accepted sequence in the ovarian cycle, so this statement is correct.
"Follicular stimulating hormone (FSH) is necessary for the development of the granulosa layer" is also accepted fact, FSH acts on the granulosa cells to drive their growth and to help start estrogen production, so this statement is correct too.
"Estradiol is formed from androgens in the ovarian follicle" reflects the two cell, two gonadotropin idea, theca cells make androgens, and these are converted to estradiol nearby in the follicle, so this statement is also correct.
That leaves "Atretic follicles are formed after atrophy of corpus luteum." Atresia is the degeneration of follicles that never reach ovulation in the first place, and it happens continuously throughout the cycle among the non selected follicles. It is not tied to, or triggered by, the corpus luteum breaking down into the corpus albicans, so describing atretic follicles as forming only after corpus luteum atrophy misstates how atresia actually works.

Step 4: Final Answer.
The statement that is NOT correct is "Atretic follicles are formed after atrophy of corpus luteum," since atresia is a separate, ongoing process among follicles that never ovulate, unrelated to the corpus luteum's own decline.