Question:
Which of the following statements about Wilson's disease is true?
Which of the following statements about Wilson's disease is true?
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Copper cannot board ceruloplasmin so blood ceruloplasmin is low, and free copper leaks into urine.
Updated On: Jun 24, 2026
- Low serum ceruloplasmin and low urinary copper
- Low serum ceruloplasmin and high urinary copper
- High serum ceruloplasmin and low urinary copper
- High serum ceruloplasmin and high urinary copper
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The Correct Option is B
Solution and Explanation
Step 1: Wilson's disease is an inherited defect of copper transport. The ATP7B gene fault stops copper from being loaded onto ceruloplasmin and excreted in bile, so copper builds up in liver, brain, and the eyes (Kayser-Fleischer rings).
Step 2: Because copper cannot be incorporated into ceruloplasmin, the level of circulating ceruloplasmin is low. So the serum ceruloplasmin is low.
Step 3: The excess copper not bound to ceruloplasmin circulates as free copper and spills into the urine. So the urinary copper excretion is high.
Step 4: Combining these two, the correct profile is low serum ceruloplasmin with high urinary copper. This matches option B.
Step 5: Why the others are wrong. Options C and D both state high ceruloplasmin, which is the opposite of the disease, so they are wrong. Option A pairs the correct low ceruloplasmin with low urinary copper, but urinary copper is actually high because free copper is dumped into the urine, so A is wrong.
Answer: Option B.
Step 2: Because copper cannot be incorporated into ceruloplasmin, the level of circulating ceruloplasmin is low. So the serum ceruloplasmin is low.
Step 3: The excess copper not bound to ceruloplasmin circulates as free copper and spills into the urine. So the urinary copper excretion is high.
Step 4: Combining these two, the correct profile is low serum ceruloplasmin with high urinary copper. This matches option B.
Step 5: Why the others are wrong. Options C and D both state high ceruloplasmin, which is the opposite of the disease, so they are wrong. Option A pairs the correct low ceruloplasmin with low urinary copper, but urinary copper is actually high because free copper is dumped into the urine, so A is wrong.
Answer: Option B.
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