Question:
Which of the following pairs of codon is correct for chain initiation in protein synthesis?
Which of the following pairs of codon is correct for chain initiation in protein synthesis?
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Initiation codons: Primary = AUG, Alternate (prokaryotes) = GUG; Stop codons: UAA (ochre), UAG (amber), UGA (opal).
Updated On: Sep 15, 2026
- AUG and GUG
- AUG and UAA
- UAG and GUG
- UAA and GUG
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Translation initiation requires specific triplet nucleotide codons on mRNA recognized by initiator tRNA.
Step 2: Detailed Explanation:
AUG is the universal primary start/initiation codon coding for Methionine in eukaryotes and N-formylmethionine (fMet) in prokaryotes.
In prokaryotes, GUG (which normally codes for valine internally) also functions as an alternative initiator codon when positioned near the Shine-Dalgarno ribosomal binding sequence.
UAA, UAG, and UGA are chain-terminating stop/nonsense codons.
Step 3: Final Answer:
Therefore, the correct pair of initiation codons is AUG and GUG.
Translation initiation requires specific triplet nucleotide codons on mRNA recognized by initiator tRNA.
Step 2: Detailed Explanation:
AUG is the universal primary start/initiation codon coding for Methionine in eukaryotes and N-formylmethionine (fMet) in prokaryotes.
In prokaryotes, GUG (which normally codes for valine internally) also functions as an alternative initiator codon when positioned near the Shine-Dalgarno ribosomal binding sequence.
UAA, UAG, and UGA are chain-terminating stop/nonsense codons.
Step 3: Final Answer:
Therefore, the correct pair of initiation codons is AUG and GUG.
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