Question:
Which of the following newer drugs has activity on both HER1 and HER2 receptors?
Which of the following newer drugs has activity on both HER1 and HER2 receptors?
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Used in HER2-positive breast cancer and also hits EGFR: think dual inhibitor.
Updated On: Jun 24, 2026
- Erlotinib
- Gefitinib
- Canertinib
- Lapatinib
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The Correct Option is D
Solution and Explanation
Step 1: HER1 is the same as EGFR, and HER2 is the same as ErbB2/neu. The question asks for a single drug that inhibits the tyrosine kinase of both receptors.
Step 2: Lapatinib is a dual tyrosine kinase inhibitor that blocks both HER1 (EGFR) and HER2. It is used in HER2-positive breast cancer, often with capecitabine. So option D is correct.
Step 3: Erlotinib (A) and gefitinib (B) are selective inhibitors of HER1 (EGFR) only and are used mainly in non-small-cell lung cancer. They do not target HER2. So A and B are wrong.
Step 4: Canertinib (C) is an irreversible pan-ErbB inhibitor that was investigational and never reached routine clinical use. Among the listed approved drugs, lapatinib is the established dual HER1/HER2 agent intended by this question. So C is not the intended answer.
Conclusion: The drug with activity on both HER1 and HER2 is lapatinib, option D.
Step 2: Lapatinib is a dual tyrosine kinase inhibitor that blocks both HER1 (EGFR) and HER2. It is used in HER2-positive breast cancer, often with capecitabine. So option D is correct.
Step 3: Erlotinib (A) and gefitinib (B) are selective inhibitors of HER1 (EGFR) only and are used mainly in non-small-cell lung cancer. They do not target HER2. So A and B are wrong.
Step 4: Canertinib (C) is an irreversible pan-ErbB inhibitor that was investigational and never reached routine clinical use. Among the listed approved drugs, lapatinib is the established dual HER1/HER2 agent intended by this question. So C is not the intended answer.
Conclusion: The drug with activity on both HER1 and HER2 is lapatinib, option D.
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