Question:
Which of the following is true about gastric carcinoma?
Which of the following is true about gastric carcinoma?
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Gastric cancer is an adenocarcinoma, often radioresistant, bleeds occultly, and arises on a low-acid stomach.
Updated On: Jun 24, 2026
- Occult bleeding in stool is not seen
- It is associated with achlorhydria or hypochlorhydria
- It is always squamous cell carcinoma
- It is radiosensitive
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The Correct Option is B
Solution and Explanation
Step 1: Recall the histology of gastric cancer. The overwhelming majority of gastric carcinomas are adenocarcinomas arising from glandular mucosa, not squamous cell carcinomas. This eliminates option C.
Step 2: Consider gastric acid status. Chronic atrophic gastritis, pernicious anemia and Helicobacter pylori associated atrophy reduce acid output, producing achlorhydria or hypochlorhydria, and these are well recognized risk factors and associations of gastric adenocarcinoma. This supports option B.
Step 3: Consider bleeding. Gastric carcinoma frequently ulcerates and causes chronic blood loss, so occult blood in the stool is commonly positive. This makes option A false.
Step 4: Consider radiotherapy. Gastric adenocarcinoma is relatively radioresistant, and surgery is the mainstay of curative treatment, so option D is false.
Conclusion: The only true statement is option B, association with achlorhydria or hypochlorhydria.
Step 2: Consider gastric acid status. Chronic atrophic gastritis, pernicious anemia and Helicobacter pylori associated atrophy reduce acid output, producing achlorhydria or hypochlorhydria, and these are well recognized risk factors and associations of gastric adenocarcinoma. This supports option B.
Step 3: Consider bleeding. Gastric carcinoma frequently ulcerates and causes chronic blood loss, so occult blood in the stool is commonly positive. This makes option A false.
Step 4: Consider radiotherapy. Gastric adenocarcinoma is relatively radioresistant, and surgery is the mainstay of curative treatment, so option D is false.
Conclusion: The only true statement is option B, association with achlorhydria or hypochlorhydria.
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