Step 1: Understanding the Concept:
Biomolecules and endocrine hormones are categorized chemically into peptide/protein, steroid, amino acid derivative, and lipid classes.
Step 2: Detailed Explanation:
1. Insulin: A peptide/protein hormone composed of 51 amino acids organized into two polypeptide chains (A chain of 21 amino acids and B chain of 30 amino acids) linked by disulfide bonds.
2. Estrogen and Testosterone: Steroid hormones synthesized from cholesterol.
3. Vitamin D-3 (Cholecalciferol): A secosteroid hormone precursor.
Thus, Insulin is proteinaceous in nature.
Step 3: Final Answer:
Therefore, Insulin is protein in nature, corresponding to option (B).