Question:
Which of the following is a Partial Fatty acid oxidation (pFox) inhibitor:
Which of the following is a Partial Fatty acid oxidation (pFox) inhibitor:
Updated On: Jul 14, 2026
- Trimetazidine
- Atosiban
- Verapamil
- Nicardipine
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The Correct Option is A
Approach Solution - 1
The correct option is (A): Trimetazidine.
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The question asks which drug acts as a partial fatty acid oxidation (pFOX) inhibitor. Let's check the actual mechanism of each drug listed.
- Trimetazidine: This anti-anginal drug works by partially inhibiting long-chain 3-ketoacyl-CoA thiolase, a key enzyme in fatty acid beta-oxidation. By shifting the heart's energy metabolism away from fatty acid oxidation and toward glucose oxidation, which produces more ATP per unit of oxygen used, it improves cardiac efficiency during ischemia. This is exactly the pFOX inhibitor mechanism.
- Atosiban: This drug is an oxytocin receptor antagonist used to delay preterm labor. It has no effect on fatty acid metabolism.
- Verapamil: This is a calcium channel blocker used for hypertension, angina, and arrhythmias. It works by blocking calcium entry into cardiac and vascular smooth muscle cells, not by altering fatty acid oxidation.
- Nicardipine: This is also a calcium channel blocker, primarily a vasodilator used for hypertension and angina. Like verapamil, its action is on calcium channels, not fatty acid metabolism.
Only trimetazidine works through the metabolic pFOX mechanism; the other three drugs act through entirely different receptor or channel targets.
Therefore, the correct answer is Trimetazidine.
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