Question:

Which of the following hormone can be used for superovulation in cattle
A. FSH
B. PMSG
C. GnRH
D. Progesterone
E. Estrogen
Choose the correct answer from the options given below:

Show Hint

FSH and eCG (PMSG) are the only two gonadotropins possessing sufficient follicle-stimulating activity to support the development of multiple dominant follicles required for superovulation.
  • A, B and C only
  • A, B and D only
  • C and D only
  • A and B only
Show Solution
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The Correct Option is D

Solution and Explanation

Step 1: Understanding the Concept:
Superovulation is the pharmacological induction of multiple follicular ovulations in a single estrous cycle.
It is the cornerstone of embryo transfer technology in cattle, aiming to maximize the yield of viable embryos from donor cows.

Step 2: Detailed Explanation:

To induce superovulation, exogenous hormones with strong follicle-stimulating activity are administered to rescue antral follicles from atresia:
- A. Follicle Stimulating Hormone (FSH): This is a pituitary gonadotropin that binds to FSH receptors on granulosa cells, promoting follicular development and recruitment. It is the most common hormone used for superovulation.
- B. Pregnant Mare Serum Gonadotropin (PMSG eCG): Produced by endometrial cups in pregnant mares, it possesses strong FSH-like activity in other species due to its high carbohydrate content and long half-life. It is used as an alternative agent to induce superovulation.
- C. GnRH (Gonadotropin Releasing Hormone) is used to induce LH surge and ovulation, not to recruit multiple follicles.
- D. Progesterone is used for estrus synchronization, not follicle stimulation.
- E. Estrogen is used to manipulate follicular waves or synchronize estrus, but cannot directly induce superovulation.
Thus, only FSH and PMSG are utilized as superovulating agents.

Step 3: Final Answer:

The hormones used for superovulation are FSH and PMSG (A and B only).
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