Question:
Which of the following drugs is used for the long term management of obesity?
Which of the following drugs is used for the long term management of obesity?
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Consider which drug class acts on GLP-1 receptors to reduce appetite and is approved for weight management.
Updated On: Jun 23, 2026
- Sibutramine
- Fenfluramine
- Metformin
- Liraglutide
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The Correct Option is D
Solution and Explanation
Step 1: Identify the clinical need. The question asks for a drug currently approved for long-term obesity management.
Step 2: Evaluate each option.
Sibutramine -- a serotonin-norepinephrine reuptake inhibitor; withdrawn globally due to increased risk of myocardial infarction and stroke.
Fenfluramine -- a serotonin-releasing agent; banned because of cardiac valvulopathy and pulmonary hypertension.
Metformin -- biguanide antidiabetic; causes modest weight reduction but is not approved as an anti-obesity drug.
Liraglutide (Saxenda, 3 mg SC daily) -- a GLP-1 receptor agonist that suppresses appetite via hypothalamic GLP-1 receptors and slows gastric emptying; approved by FDA and EMA for long-term weight management.
Step 3: Conclusion. Liraglutide is the correct answer as the only option listed that is currently approved for long-term obesity management.
Step 2: Evaluate each option.
Sibutramine -- a serotonin-norepinephrine reuptake inhibitor; withdrawn globally due to increased risk of myocardial infarction and stroke.
Fenfluramine -- a serotonin-releasing agent; banned because of cardiac valvulopathy and pulmonary hypertension.
Metformin -- biguanide antidiabetic; causes modest weight reduction but is not approved as an anti-obesity drug.
Liraglutide (Saxenda, 3 mg SC daily) -- a GLP-1 receptor agonist that suppresses appetite via hypothalamic GLP-1 receptors and slows gastric emptying; approved by FDA and EMA for long-term weight management.
Step 3: Conclusion. Liraglutide is the correct answer as the only option listed that is currently approved for long-term obesity management.
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