Question:
Which of the following are the examples of amide linked local anaesthetic?
A. Tetracaine
B. Lidocaine
C. Bupivacaine
D. Hexacaine
E. Mepivacaine
Choose the correct answer from the options given below:
Which of the following are the examples of amide linked local anaesthetic?
A. Tetracaine
B. Lidocaine
C. Bupivacaine
D. Hexacaine
E. Mepivacaine
Choose the correct answer from the options given below:
A. Tetracaine
B. Lidocaine
C. Bupivacaine
D. Hexacaine
E. Mepivacaine
Choose the correct answer from the options given below:
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A useful chemical nomenclature rule: generic names of amide local anesthetics contain the letter "i" twice (e.g., lidocaine, bupivacaine, mepivacaine).
Ester local anesthetics only have the letter "i" once before "-caine" (e.g., procine, tetracine).
Ester local anesthetics only have the letter "i" once before "-caine" (e.g., procine, tetracine).
Updated On: Aug 13, 2026
- A, B and D only
- B, C and E only
- A and D only
- C and E only
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept:
Local anesthetics are clinically categorized based on their chemical linkage between the lipophilic aromatic ring and the hydrophilic amine group into two classes:
1. Esters (e.g., Procaine, Tetracaine, Cocaine).
2. Amides (e.g., Lidocaine, Bupivacaine, Mepivacaine).
Step 2: Detailed Explanation:
Let us classify the given local anesthetics:
- A. Tetracaine: Contains an ester linkage. It is metabolized by plasma pseudocholinesterases.
- B. Lidocaine: Contains an amide linkage. It is highly stable and metabolized in the liver.
- C. Bupivacaine: Contains an amide linkage. It provides prolonged duration of block but is cardiotoxic if given intravenously.
- D. Hexacaine: Contains an ester linkage.
- E. Mepivacaine: Contains an amide linkage. It has a medium duration of action and produces minimal vasodilation.
Thus, the amide-linked anesthetics among the choices are Lidocaine, Bupivacaine, and Mepivacaine (B, C, and E).
Step 3: Final Answer:
The correct combination is B, C and E only.
Local anesthetics are clinically categorized based on their chemical linkage between the lipophilic aromatic ring and the hydrophilic amine group into two classes:
1. Esters (e.g., Procaine, Tetracaine, Cocaine).
2. Amides (e.g., Lidocaine, Bupivacaine, Mepivacaine).
Step 2: Detailed Explanation:
Let us classify the given local anesthetics:
- A. Tetracaine: Contains an ester linkage. It is metabolized by plasma pseudocholinesterases.
- B. Lidocaine: Contains an amide linkage. It is highly stable and metabolized in the liver.
- C. Bupivacaine: Contains an amide linkage. It provides prolonged duration of block but is cardiotoxic if given intravenously.
- D. Hexacaine: Contains an ester linkage.
- E. Mepivacaine: Contains an amide linkage. It has a medium duration of action and produces minimal vasodilation.
Thus, the amide-linked anesthetics among the choices are Lidocaine, Bupivacaine, and Mepivacaine (B, C, and E).
Step 3: Final Answer:
The correct combination is B, C and E only.
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