Question

Which of the following antipsychotic drugs works by blocking post-synaptic dopamine D2 receptors, particularly in the mesolimbic-mesocortical pathway?

• A. Haloperidol
• B. Clozapine
• C. Olanzapine
• D. Risperidone

Hint:

Haloperidol is a typical antipsychotic, while others like Clozapine and Risperidone are atypical antipsychotics.

Answer 1

The Correct Option is A

Haloperidol is a typical antipsychotic drug that works by blocking the D2 dopamine receptors in the brain, especially in the mesolimbic-mesocortical pathways. This is essential in the management of schizophrenia and other psychotic disorders. Clozapine, Olanzapine, and Risperidone are atypical antipsychotics that have a different mechanism, as they affect multiple neurotransmitter systems, including serotonin and dopamine. Thus, the correct answer is (a) Haloperidol.