Question:
Which among the following is used for the diagnosis of antiphospholipid antibody syndrome?
Which among the following is used for the diagnosis of antiphospholipid antibody syndrome?
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Recall the three APS lab criteria; do not confuse beta 2 glycoprotein I with beta 2 microglobulin.
Updated On: Jun 24, 2026
- Beta 2 microglobulin antibody
- Anti nuclear antibody
- Anti centromere antibody
- Anti beta 2 glycoprotein I antibody
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Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Antiphospholipid antibody syndrome (APS) is diagnosed by combining a clinical criterion (vascular thrombosis or pregnancy morbidity) with a laboratory criterion (a persistently positive antiphospholipid antibody).
Step 2: The three accepted laboratory tests (Sapporo/Sydney criteria) are lupus anticoagulant, anticardiolipin antibody, and anti-beta 2 glycoprotein I antibody, each confirmed on two occasions at least 12 weeks apart.
Step 3: Among the options offered, anti-beta 2 glycoprotein I antibody is one of these defining laboratory criteria for APS.
Step 4: Beta 2 microglobulin (option A) is unrelated; it is a marker used in renal and myeloma assessment, not APS, and must not be confused with beta 2 glycoprotein I.
Step 5: Antinuclear antibody (option B) is a screening test for systemic lupus erythematosus and other connective tissue diseases, and anti-centromere antibody (option C) is associated with limited cutaneous systemic sclerosis (CREST); neither defines APS.
Conclusion: The correct answer is anti beta 2 glycoprotein I antibody.
Step 2: The three accepted laboratory tests (Sapporo/Sydney criteria) are lupus anticoagulant, anticardiolipin antibody, and anti-beta 2 glycoprotein I antibody, each confirmed on two occasions at least 12 weeks apart.
Step 3: Among the options offered, anti-beta 2 glycoprotein I antibody is one of these defining laboratory criteria for APS.
Step 4: Beta 2 microglobulin (option A) is unrelated; it is a marker used in renal and myeloma assessment, not APS, and must not be confused with beta 2 glycoprotein I.
Step 5: Antinuclear antibody (option B) is a screening test for systemic lupus erythematosus and other connective tissue diseases, and anti-centromere antibody (option C) is associated with limited cutaneous systemic sclerosis (CREST); neither defines APS.
Conclusion: The correct answer is anti beta 2 glycoprotein I antibody.
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