Question:
Which among the following is not used to treat alcohol dependence?
Which among the following is not used to treat alcohol dependence?
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One option is a benzodiazepine antagonist, not an anti-craving or aversive agent.
Updated On: Jun 24, 2026
- Flumazenil
- Acamprosate
- Naltrexone
- Disulfiram
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The Correct Option is A
Solution and Explanation
Step 1: This is a negative-stem question asking which drug is NOT used in the pharmacological management of alcohol dependence.
Step 2: The three established anti-craving or aversive agents are: Acamprosate, which stabilises glutamate or GABA balance to reduce craving and maintain abstinence; Naltrexone, an opioid antagonist that reduces the rewarding effect of alcohol and craving; and Disulfiram, which inhibits aldehyde dehydrogenase to produce an unpleasant acetaldehyde reaction on drinking, acting as a deterrent.
Step 3: Flumazenil is a benzodiazepine receptor antagonist used to reverse benzodiazepine sedation or overdose. It has no established role in treating alcohol dependence; in fact it can precipitate seizures in patients with alcohol-related benzodiazepine use or dependence.
Step 4: Therefore the drug not used for alcohol dependence is Flumazenil.
Step 2: The three established anti-craving or aversive agents are: Acamprosate, which stabilises glutamate or GABA balance to reduce craving and maintain abstinence; Naltrexone, an opioid antagonist that reduces the rewarding effect of alcohol and craving; and Disulfiram, which inhibits aldehyde dehydrogenase to produce an unpleasant acetaldehyde reaction on drinking, acting as a deterrent.
Step 3: Flumazenil is a benzodiazepine receptor antagonist used to reverse benzodiazepine sedation or overdose. It has no established role in treating alcohol dependence; in fact it can precipitate seizures in patients with alcohol-related benzodiazepine use or dependence.
Step 4: Therefore the drug not used for alcohol dependence is Flumazenil.
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