Question

What is the recommended dose of equine rabies immunoglobulin for post-exposure prophylaxis?

• A. 10 IU/kg
• B. 20 IU/kg
• C. 30 IU/kg
• D. 40 IU/kg

Hint:

Equine RIG is 20 IU/kg; F(ab)2 products are 40 IU/kg.

Answer 1

The Correct Option is B

Step 1: Rabies immunoglobulin (RIG) gives passive immunity and is infiltrated into and around wounds in category III exposures, buying time until the active vaccine generates antibodies.

Step 2: Two preparations exist. Equine RIG (purified horse serum) is given at a dose of \(20\ \text{IU/kg}\) body weight, while human RIG is given at \(20\ \text{IU/kg}\) as well. The question specifies rabies immunoglobulin at 20 IU/kg, matching option b.

Step 3: Note that F(ab)2 fragment products are dosed at \(40\ \text{IU/kg}\), which is why 40 IU/kg is a tempting distractor but refers to a different product.

Step 4: Therefore the correct dose is 20 IU/kg, option b.