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Pathophysiology
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Classification of infectious diseases
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what is the proposed mechanism of action of artemi
Question:
What is the proposed mechanism of action of artemisinin in the treatment of malaria:
GPAT - 2024
GPAT
Updated On:
Jul 22, 2024
Inhibition of dihydrofolate reductase, interfering with folate synthesis
Blocking of the Plasmodium falciparum ATPase, disrupting ion homeostasis
Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
Inhibition of the heme polymerase enzyme, causing accumulation of toxic heme
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The Correct Option is
C
Solution and Explanation
The correct option is (C): Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death .
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