Question:
What is the choice of treatment for idiopathic thrombocytopenic purpura (ITP)?
What is the choice of treatment for idiopathic thrombocytopenic purpura (ITP)?
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The organ that both destroys platelets and makes the antibody.
Updated On: Jun 23, 2026
- Blood transfusion
- Spontaneous recovery
- IV infusion
- Splenectomy
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The Correct Option is D
Solution and Explanation
Step 1: Immune (idiopathic) thrombocytopenic purpura is caused by autoantibodies against platelet surface glycoproteins. The spleen is both the major site of antibody coated platelet destruction and a major source of the autoantibody. Step 2: First line therapy is medical (corticosteroids, IV immunoglobulin), but in chronic or refractory ITP the definitive treatment is splenectomy. Step 3: Removing the spleen takes away both the main site of platelet destruction and a key source of autoantibody synthesis, which restores the platelet count in a large proportion of patients. Step 4: Blood transfusion, waiting for spontaneous recovery, and simple IV infusion are not the definitive treatment of chronic ITP, so they are wrong. Splenectomy is correct.
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