Question:

To assess the function of liver, we can use following tests in dog
A. BSP clearance test
B. Estimation of LDH enzyme
C. Estimation of bilirubin
D. Trypsin test
E. Test for malabsorption of intestine
Choose the correct answer from the options given below:

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Liver Function Tests in Dogs:
Excretory/Clearance = BSP clearance, Bile acids, Serum Bilirubin.
Synthetic = Albumin, BUN, Coagulation factors. (Trypsin is for Pancreas).
  • B and D only
  • D and E only
  • A and C only
  • B and E only
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The Correct Option is C

Solution and Explanation


Step 1: Understanding the Concept:

Hepatic function and biliary clearance testing in small animal clinical biochemistry.

Step 2: Detailed Explanation:

Evaluating liver function tests (LFTs) in canines:
1. A. Sulfobromophthalein (BSP) Clearance Test: A true test of hepatic excretory function; assesses hepatic blood flow, hepatocyte uptake, intracellular conjugation, and biliary excretion of an injected dye ($< 5\%$ retention at 30 min is normal in dogs).
2. C. Estimation of Serum Bilirubin (Total, Direct, Indirect): Standard marker of hepatic uptake, conjugation capacity, and post-hepatic biliary patency.
3. Trypsin tests assess exocrine pancreatic function (EPI); malabsorption tests assess intestinal villous enteropathy.
Thus, tests A and C only directly assess liver function.

Step 3: Final Answer:

Hence, the liver function tests are A and C only, matching option (C).
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