Question:

The symbol "W" in the TWC stem-loop of the tRNA denotes which one of the following?

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TWC stem-loop:
- T = Ribothymidine
- \(\Psi\) = Pseudouridine
- C = Cytidine
- This region is conserved in tRNA structure.
  • Pseudouridine
  • Thiouridine
  • Ribothymidine
  • Inosine
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The Correct Option is C

Solution and Explanation

Step 1: Understanding the Question:
This question tests knowledge of tRNA structure and modified bases.

Step 2: Detailed Explanation:

The TWC stem-loop is a conserved region in tRNA.
The letter "W" in TWC stands for ribothymidine (T).
The other symbols: \(\Psi\) denotes pseudouridine, and C denotes cytidine.
Thus, the sequence TWC = Ribothymidine-Pseudouridine-Cytidine.
Pseudouridine (A) is represented by \(\Psi\), not W.
Thiouridine (B) is a sulfur-containing modified base.
Inosine (D) is found in the anticodon loop.
Thus, the correct answer is ribothymidine.

Step 3: Final Answer:

Thus, the symbol "W" denotes ribothymidine, which corresponds to option (C).
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