Question:
The situation where the end product of biochemical pathway inhibits the activity of an enzyme catalyzing the first reaction of the pathway is termed as -
The situation where the end product of biochemical pathway inhibits the activity of an enzyme catalyzing the first reaction of the pathway is termed as -
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Feedback inhibition is an example of allosteric regulation.
Because the end-product binds to a non-catalytic "allosteric" site (and not the active site), it acts as a non-competitive or mixed inhibitor, allowing rapid, reversible regulation of metabolism.
Because the end-product binds to a non-catalytic "allosteric" site (and not the active site), it acts as a non-competitive or mixed inhibitor, allowing rapid, reversible regulation of metabolism.
Updated On: Aug 20, 2026
- Feedback inhibition
- Competitive inhibition
- Feedback repression
- Uncompetitive inhibition
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Cells regulate metabolic pathways to prevent the overproduction of specific biochemical metabolites, conserving energy and raw materials.
Step 2: Detailed Explanation:
- Feedback inhibition (or end-product inhibition) is a cellular control mechanism where the final end-product of a multi-step biochemical pathway binds to an allosteric site of the regulatory enzyme that catalyzes the first committed step of that same pathway.
- This binding alters the enzyme's conformation, decreasing its catalytic activity and effectively shutting down the entire pathway when the concentration of the end-product is high.
- Feedback repression involves stopping the *synthesis* of the enzyme at the gene transcription level, rather than inhibiting an already active enzyme molecule.
Step 3: Final Answer:
This biochemical inhibition situation is termed feedback inhibition, which corresponds to option (A).
Cells regulate metabolic pathways to prevent the overproduction of specific biochemical metabolites, conserving energy and raw materials.
Step 2: Detailed Explanation:
- Feedback inhibition (or end-product inhibition) is a cellular control mechanism where the final end-product of a multi-step biochemical pathway binds to an allosteric site of the regulatory enzyme that catalyzes the first committed step of that same pathway.
- This binding alters the enzyme's conformation, decreasing its catalytic activity and effectively shutting down the entire pathway when the concentration of the end-product is high.
- Feedback repression involves stopping the *synthesis* of the enzyme at the gene transcription level, rather than inhibiting an already active enzyme molecule.
Step 3: Final Answer:
This biochemical inhibition situation is termed feedback inhibition, which corresponds to option (A).
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