Question:

The process of mitosis in a cell consists of a series of events as given below. Arrange the events in order from first to the last as per the time of occurrence
A. The highly condensed chromosomes move to the equatorial plate of the spindle
B. The centromere interacts with the spindle fiber apparatus
C. Division of the cytoplast
D. Sister chromatids move apart to the oppositive poles
E. The nuclear membrane breaks down and the spindle-shaped structure of microtubules is organized
Choose the correct answer from the options given below:

Show Hint

Remember the classic stages of mitosis: Prophase $\rightarrow$ Prometaphase $\rightarrow$ Metaphase $\rightarrow$ Anaphase $\rightarrow$ Telophase $\rightarrow$ Cytokinesis. Cytokinesis (division of the cytoplast) is always the final step.
  • A, B, C, D, E
  • E, B, A, D, C
  • E, A, B, D, C
  • D, B, A, E, C
Show Solution
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The Correct Option is B

Solution and Explanation

Step 1: Understanding the Concept:
Mitosis is a process of nuclear division (karyokinesis) followed by cytoplasmic division (cytokinesis) that produces two genetically identical daughter cells. The stages must proceed in a precise order.

Step 2: Detailed Explanation:

Let us reconstruct the step-by-step sequence of mitotic events:
1. Prophase Prometaphase (E): The nuclear membrane breaks down, allowing the mitotic spindle fibers (composed of microtubules) to organize into a bipolar spindle-shaped structure.
2. Prometaphase (B): The kinetochores located on the centromere of each chromosome interact with and attach to the growing spindle fibers.
3. Metaphase (A): Chromosomes, now fully condensed, are aligned along the equatorial plate of the cell by the opposing forces of the spindle fibers.
4. Anaphase (D): Sister chromatids split at the centromere and are pulled to opposite poles of the cell.
5. Cytokinesis (C): The cytoplast (cytoplasm) divides, separating the single binucleated cell into two distinct daughter cells.
This chronological sequence corresponds to the order: E, B, A, D, C.

Step 3: Final Answer:

Hence, the correct sequence of events is E, B, A, D, C.
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