Question

The maximum dose rate of lignocaine hydrochloride in goat should not exceed

• A. 20 mg/kg Body Weight
• B. 30 mg/kg Body Weight
• C. 10 mg/kg Body Weight
• D. 40 mg/kg Body Weight

Hint:

Lignocaine Maximum Safe Limits: Goat/Sheep = Max $10\text{ mg/kg}$ (dilute to $1\%$). Dog = $10\text{ mg/kg}$. Horse = $10\text{ mg/kg}$. Small ruminants are highly sensitive.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Small ruminant toxicological sensitivity to local anesthetics: caprine species exhibit high susceptibility to systemic neuro- and cardiotoxicity from local amino-amide anesthetics.
Key Formula or Approach:
\[ \text{Maximum Safe Dose of Lignocaine in Goats} \le 5 - 10\text{ mg/kg Body Weight} \]

Step 2: Detailed Explanation:
In caprine regional anesthesia and pharmacology:
- Goats and sheep are exceptionally sensitive to systemic Lignocaine (Lidocaine) toxicity (manifesting as muscle tremors, depression, convulsions, respiratory arrest, and cardiac arrhythmias).
- In canine and equine species, maximum doses reach $10 - 20\text{ mg/kg}$.
- However, in the Goat, the cumulative maximum safe ceiling dose must never exceed 10 mg/kg Body Weight (with clinical conservative maximums strictly maintained between $5\text{ to } 10\text{ mg/kg}$, frequently diluted with sterile saline to $0.5 - 1\%$ to provide sufficient infiltration volume).

Step 3: Final Answer:
Therefore, the maximum dose rate in goats should not exceed 10 mg/kg Body Weight, corresponding to option (C).