The parabola \( y^2 = 16x \) opens to the right along the positive \( x \)-axis, since it is of the form \( y^2 = 4ax \) with a positive coefficient. Let's check each of the given coordinates against this orientation and the general focus relation where \( 4a \) equals the coefficient of \( x \).
Only \( (4, 0) \) is consistent both with the axis along which \( y^2 = 16x \) opens and with the coefficient \( 16 \) matching \( 4a \).
Therefore, the correct answer is \( (4, 0) \).