Question:
The first line treatment of infertility in PCOS is?
The first line treatment of infertility in PCOS is?
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An oral anti-estrogen that induces ovulation comes first.
Updated On: Jun 24, 2026
- Clomiphene
- FSH
- GnRH
- Assisted reproductive techniques
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The Correct Option is A
Solution and Explanation
Step 1: Infertility in polycystic ovary syndrome (PCOS) is mainly due to anovulation. The goal of treatment is therefore to induce ovulation.
Step 2: Clomiphene citrate is a selective estrogen receptor modulator. It blocks estrogen receptors at the hypothalamus, removing negative feedback so that FSH and LH rise and stimulate follicular growth and ovulation.
Step 3: Because it is oral, inexpensive and effective, clomiphene citrate is the first line agent for ovulation induction in an anovulatory PCOS woman, usually after lifestyle and weight measures.
Step 4: Injectable gonadotropins (FSH), GnRH and assisted reproductive techniques such as IVF are reserved for women who fail to ovulate or conceive on first line therapy. Hence the answer is clomiphene.
Step 2: Clomiphene citrate is a selective estrogen receptor modulator. It blocks estrogen receptors at the hypothalamus, removing negative feedback so that FSH and LH rise and stimulate follicular growth and ovulation.
Step 3: Because it is oral, inexpensive and effective, clomiphene citrate is the first line agent for ovulation induction in an anovulatory PCOS woman, usually after lifestyle and weight measures.
Step 4: Injectable gonadotropins (FSH), GnRH and assisted reproductive techniques such as IVF are reserved for women who fail to ovulate or conceive on first line therapy. Hence the answer is clomiphene.
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