Question:

The enzyme that synthesizes DNA at the ends of chromosomes in eukaryotes is

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Telomerase:
- Adds telomeric repeats to chromosome ends.
- Prevents telomere shortening during replication.
- Active in stem cells and cancer cells.
  • Telomerase
  • Holoenzyme
  • RNA primase
  • Endonuclease
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the Question:
This question tests knowledge of DNA replication at chromosome ends.

Step 2: Detailed Explanation:

Telomerase synthesizes DNA at the ends of chromosomes (telomeres).
It adds repeated DNA sequences to the 3' end of chromosomes.
It contains RNA template for reverse transcription.
Prevents shortening of telomeres during replication.
Holoenzyme (B): A multi-subunit enzyme complex.
RNA primase (C): Synthesizes RNA primers for DNA replication.
Endonuclease (D): Cleaves DNA at specific sites.
Thus, telomerase is the correct answer.

Step 3: Final Answer:

Thus, telomerase synthesizes DNA at chromosome ends, which corresponds to option (A).
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