Question:
The adverse effect of xylazine hydrochloride is reversed with the use of
A. Neostigmine
B. Atropine sulphate
C. Acetyl choline
D. Yohimbine hydrochloride
E. Dopamine
Choose the correct answer from the options given below:
The adverse effect of xylazine hydrochloride is reversed with the use of
A. Neostigmine
B. Atropine sulphate
C. Acetyl choline
D. Yohimbine hydrochloride
E. Dopamine
Choose the correct answer from the options given below:
A. Neostigmine
B. Atropine sulphate
C. Acetyl choline
D. Yohimbine hydrochloride
E. Dopamine
Choose the correct answer from the options given below:
Show Hint
Alpha-2 Agonists & Specific Reversals:
Xylazine $\leftrightarrow$ Yohimbine Tolazoline.
Medetomidine Dexmedetomidine $\leftrightarrow$ Atipamezole (Antisedan).
Xylazine $\leftrightarrow$ Yohimbine Tolazoline.
Medetomidine Dexmedetomidine $\leftrightarrow$ Atipamezole (Antisedan).
Updated On: Sep 7, 2026
- A and C
- B and E
- C only
- D only
Show Solution
Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Reversal of $lpha_2$-adrenoceptor agonist sedative-analgesics using competitive competitive central $lpha_2$-antagonists.
Step 2: Detailed Explanation:
Pharmacology of $\alpha_2$-adrenergic reversal agents:
- Xylazine Hydrochloride is a potent, selective $\alpha_2$-adrenoceptor agonist widely used in veterinary anesthesia for sedation, muscle relaxation, and analgesia (adverse effects include bradycardia, hypotension, respiratory depression, rumen stasis, and bloat).
- Its sedative and toxic depressant effects are rapidly and specifically reversed by competitive selective $\alpha_2$-adrenoceptor antagonists, primarily Yohimbine Hydrochloride (D) (dose: $0.125\text{ mg/kg}$ i/v in cattle, $0.1\text{ mg/kg}$ in dogs) or Atipamezole Tolazoline.
- (Neostigmine reverses neuromuscular blockers; Atropine reverses muscarinic anticholinesterase toxicity).
Step 3: Final Answer:
Hence, the adverse effects of xylazine are reversed by D only, matching option (D).
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