Question:
Sweaty feet odour in urine is seen in?
Sweaty feet odour in urine is seen in?
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Sweaty feet odour points to isovaleric acidemia; mousy is PKU, maple syrup is MSUD.
Updated On: Jun 24, 2026
- Phenylketonuria
- Maple syrup urine disease
- Isovaleric acidemia
- Alkaptonuria
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Several inborn errors of metabolism produce characteristic body or urine odours. Match the sweaty feet (cheesy) odour to its disorder.
Step 2: Isovaleric acidemia is a defect in leucine catabolism (isovaleryl-CoA dehydrogenase). The accumulated isovaleric acid produces the classic sweaty feet odour. Glutaric aciduria can give a similar odour. So option c is correct.
Step 3: Why the others are wrong. Phenylketonuria (PKU) gives a mousy or musty odour of skin, hair and urine due to phenylacetate. Maple syrup urine disease, a branched-chain ketoaciduria, gives a burnt sugar or maple syrup odour.
Step 4: Alkaptonuria causes urine that darkens on standing (homogentisic acid) rather than a sweaty feet smell. Hence the answer is Isovaleric acidemia.
Step 2: Isovaleric acidemia is a defect in leucine catabolism (isovaleryl-CoA dehydrogenase). The accumulated isovaleric acid produces the classic sweaty feet odour. Glutaric aciduria can give a similar odour. So option c is correct.
Step 3: Why the others are wrong. Phenylketonuria (PKU) gives a mousy or musty odour of skin, hair and urine due to phenylacetate. Maple syrup urine disease, a branched-chain ketoaciduria, gives a burnt sugar or maple syrup odour.
Step 4: Alkaptonuria causes urine that darkens on standing (homogentisic acid) rather than a sweaty feet smell. Hence the answer is Isovaleric acidemia.
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